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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically described as focusing on practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographic areas. This type of heterogeneity, which is vital for pragmatic trials to be valid and lessen the chance of bias is also essential. However excessive heterogeneity could result in issues with the design of the trial.

Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market offers an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic gambling experience, as well a full variety of betting options via virtual. The company also has created various interactive games to make gambling online enjoyable. Some of these shows are broadcast live and some feature famous personalities in the industry.

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Legality

Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. Despite its infancy, it has already established itself as a premier gaming platform for casinos. Wolves is one of its latest releases, a 5-reel slot machine with a hefty RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they shouldn't be used to substitute for explanatory trials.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis as well as pragmatic trials that inform policy and practice decisions. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a practical trial which includes recruitment, design and delivery of the intervention, as well as the follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the issue of pragmatics. However, it is important to remember that the majority of these studies were conducted in primary care settings.