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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described by their focus on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and included participants from various geographical areas. This type of heterogeneity, that is crucial for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity could cause issues with the design of the trial.

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Pragmatic Play is known for its top-notch games, and for providing a superior user experience. Its software is designed to work on mobile devices and supports different languages. Despite its relative youth, it has already established itself as a leading casino gaming platform. Wolves is one of the most recent releases that is a 5-reel slot machine with a hefty RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. They are typically requested by practitioners and policymakers to inform their decisions. They can also be a great method to determine the causality between an intervention and its outcomes. However, they should not be used in lieu for the use of explanation studies.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials that inform the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study, including recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, shown in red in Figure 2. This indicates that the health science community is becoming more sensitive to the issue of pragmatics. It is important to keep in mind, however, that the majority of these studies were conducted in primary care settings.